Variations in Ischemic Heart Disease Research by Country, Income, Development and Burden of Disease: A Scientometric Approach

INTRODUCTION Ischemic heart diseases (IHDs) are the leading cause of mortality worldwide. However the global burden of IHD has been concentrated on developing countries, where limited research efforts have been made to address these needs. This study aimed to understand the global distribution of IHD research activities by looking at the countries' burden of disease, income and development data. METHODS As a scientometric study, Scopus database was searched for research publications indexed under the medical subject heading (MeSH) 'myocardial ischemia' including the following terms: coronary artery disease, coronary heart disease, and ischemic heart disease. The number of research publications in Scopus database was recorded for each individual year 2000-2012, and for each country. Data for estimated IHD disability-adjusted life-year's (DALY's), gross domestic product (GDP) per capita and human development index were also included for the analysis. RESULTS IHD research publications were most likely produced by European and Western pacific countries. High-income countries produced the greatest share of about 81% of the global IHD research. However, no significant association observed between the countries' GDP and number of research publications worldwide (OR = 0.98, P = 0.939). Global IHD research found to be strongly associated with the burden of disease (P < 0.0001) and the countries' HDI values worldwide (OR = 16.8, P = 0.016). CONCLUSION Our study suggested that global research on IHD were geographically distributed and highly concentrated among the world's richest countries. Estimated DALYs and HDI were found as important predictors of IHD research and the key drivers of health research disparities across the world.